Salmonella Typhoid toxin: Biology, Pathogenesis & Neutralization (Song Lab at Cornell; September 2014 – present)
Structure-function analysis of neutralizing antibodies that confer prophylactic and therapeutic protection against Salmonella Typhi typhoid toxin. In preparation.
The role of 9-O-acetylated glycan receptor moieties in the binding and toxicity of Salmonella Typhi typhoid toxin. In preparation.
Lee S*, Yang Y-A*, Milano SK, Nguyen T, Sim JH, Thompson AJ, Hillpot EC, Yoo G, Paulson JC, and Song J. (2019). Host adaptations of the Salmonella Typhi typhoid toxin and its orthologue from a nontyphoidal Salmonella. Cell Host & Microbe. Under review.
Yang Y, Higgins C, Rehman I, Galvao K, Brito I, Bicalho M, Song J, Wang H, and Bicalho R. (2019). The genomic diversity, virulence, and antimicrobial resistance of Klebsiella pneumoniae from cows and humans. Applied and Environmental Microbiology. 85 (6): e02654-18.
Yang Y-A, Chong A, and Song J. (2018). Why is Eradicating Typhoid Fever So Challenging: Implications for Vaccine and Therapeutic Design. Vaccines. 6 (3), 45.
Yang Y-A, Lee S, Zhao J, Thompson AJ, McBride R, Tsogtbaatar B, Paulson JC, Nussinov R, Deng L, and Song J. (2018). In vivo tropism of Salmonella Typhi toxin to cells expressing a multiantennary glycan receptor. Nature Microbiology. 3 (2): 155-163. Epub Dec 4, 2017.
Highlighted in News and Views (Nature Microbiology 3 (2): 124-126.)
Liu Y, Qi L, Qi L, Ding T, Wang Z, Fu J, Hu M, Li M, Song J**, and Liu X**. (2017). Temporal regulation of a Salmonella Typhimurium virulence factor by the transcriptional regulator YdcR. Molecular & Cellular Proteomics. 16 (9):1683-1693. (** co-senior authors).
Chong, A, Lee, S, Yang, Y-A, and Song J. (2017). The role of typhoid toxin in Salmonella Typhi virulence. Yale Journal of Biology & Medicine. 90 (2):283-290.
Chang S-J, Song J, and Galán JE. (2016). Receptor-mediated sorting of typhoid toxin during its export from Salmonella Typhi-infected cells. Cell Host & Microbe. 20 (5):682-689.
Song J*, Wilhelm CL*, Wangdi T, Maira-Litran T, Lee S-J, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Baumler AJ, Pier GB, Galán JE, and Yarovinsky F. (2016). Absence of TLR11 in mice does not confer susceptibility to Salmonella Typhi. Cell. 164 (5):827-8. (* co-first authors).
Deng L*, Song J*, Gao X*, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galán JE, and Varki A. (2014). Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Cell. 159 (6):1290-9. (* co-first authors).
Selected previous publications on the host-bacterial pathogen interaction
Typhoid toxin & Salmonella Typhi Pathogenesis (Postdoc training; January 2009-August 2014)
Song J*, Gao X*, and Galán JE. (2013). Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin. Nature. 499(7458):350-354. (* co-first authors; Highlighted in News and Views, Highlighted in Faculty 1000).
Song J*, Willinger T*, Rongvaux A, Eynon EE, Stevens S, Manz MG, Flavell RA, and Galán JE. (2010). A mouse model for the human pathogen Salmonella Typhi. Cell Host & Microbe. 8(4):369-76. (* co-first authors).
ScienceDaily: Typhoid Mary, not typhoid mouse: Enzyme protects mice, not humans from typhoid.
Medica Press: Typhoid Mary, not typhoid mouse: Lack of enzyme explains why typhoid fever is a human-specific disease
NIH RESEARCH MATTERS: Novel Structure and Function of Typhoid Toxin
Science News: Lethal Power of Typhoid Bacteria Salmonella Typhi Lies in Its Toxin
Nature News & Views: Bacteriology: Toxins in tandem
Interplay between bladder epithelial cells and uropathogenic E. coli (PhD student; 2003-2008)
Song J*, Bishop BL*, Li G, Grady R, Stapleton A, and Abraham SN. (2009). TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. Proc Natl Acad Sci USA. 106(35):14966-71. (* co-first authors).
Song J**, and Abraham SN. (2008). TLR-mediated immune responses in the urinary tract. Current Opinion in Microbiology. 11(1):66-73. (** corresponding author).
Song J**, and Abraham SN. (2008). Innate and adaptive immune responses in the urinary tract. European Journal of Clinical Investigation. 2:21-8. (** corresponding author).
Song J, Bishop BL, Li G, Duncan MJ, and Abraham SN. (2007). TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. Cell Host & Microbe. 1(4):287-298. (Highlighted as a Featured article).
Song J, Duncan MJ, Li G, Chan C, Grady R, Stapleton A, and Abraham SN. (2007). A novel TLR4 mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. PLoS Pathogens. 3(4):e60. (Highlighted as Cover Story, Highlighted in Editor’s pick).
Bishop BL, Duncan MJ, Song J, Li G, Zaas D, and Abraham SN. (2007). Cyclic AMP-regulated exocytosis of E. coli from infected bladder epithelial cells. Nature Medicine. 13(5):625-630. (Highlighted in News and Views).
Cover Story: Bladder epithelial cells exposed to E. coli.
News and Views: Flushing bacteria out of the bladder