2022
Du L and Song J. Delivery, structure, and function of bacterial genotoxins. Virulence. Accepted.
Neupane DP*, Ahn C*, Yang Y-A, Lee GY, and Song J. The role of diets in maternal vaccinations against typhoid toxin. BioRxiv https://doi.org/10.1101/2022.06.10.495645.
[in review]
Song J. Bacterial AB toxins and host-microbe interactions. Advances in Microbial Physiology Vol. 81. In press.
2021
Dulal HP*, Vance DJ*, Neupane DP*, Chen X, Tremblay JM, Shoemaker CB, Mantis NJ#, and Song J#. Neutralization of typhoid toxin by alpaca-derived, single-domain antibodies targeting the PltB and CdtB subunits. Infection & Immunity. Dec 13;AI0051521. Doi: 10.1128/IAI.00515-21.
Highlighted in Spotlight (Infection & Immunity 2022)
Lee GY and Song J. Complete genome sequence of Salmonella enterica serovar Typhi strain ISP2825. Microbiology Resource Announcements. 10:e00804-21. https://doi.org/10.1128/MRA.00804-21
NCBI Reference Sequence: NZ_CP080960.1
Kim C*, Latif I*, Neupane DP, Lee GY, Kwon RS, Batool A, Ahmed Q, Qamar MU**, and Song J**. (2021). The molecular basis of extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients. PLOS One. 16(9): e0257744. https://doi.org/10.1371/journal.pone.0257744
Nguyen T and Song J. Direct IgG epitope mapping on bacterial AB toxins by cryo-EM. STAR Protocols. 2(4):100852. https://doi.org/10.1016/j.xpro.2021.100852
Nguyen T*, Richards AF* (* co-first author), Neupane DP, Feathers JR, Yang Y-A, Sim JH, Byun H, Lee S, Ahn C, VanSlyke G, Fromme JC, Mantis NJ, and Song J. The structural basis of Salmonella A2B5 toxin neutralization by antibodies targeting the glycan-receptor binding subunits. Cell Reports. 36(10):109654. doi: 10.1016/j.celrep.2021.109654.
Structure of TyTx1 (anti-PltB IgG) bound to typhoid toxin: PDB 7K7H and EMDB-22699
Structure of TyTx4 (anti-PltB IgG) bound to typhoid toxin: PDB 7K7I and EMDB-22700
Lee S*, Inzerillo S* (* co-first author), Lee GY, Bosire EM, Mahato SK, and Song J. Glycan-Mediated Molecular Interactions in Bacterial Pathogenesis. Trends in Microbiology. Available online July 14, 2021. doi: 10.1016/j.tim.2021.06.011
Ahn C*, Yang Y-A* (* co-first author), Neupane DP, Nguyen T, Richards AF, Sim JH, Mantis NJ, and Song J. (2021). Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor-binding and nuclease subunits. iScience. 24(5), 102454. https://doi.org/10.1016/j.isci.2021.102454
Structure of TyTx11 (anti-CdtB IgG) bound to typhoid toxin: PDB 6VX4 and EMDB-21429
Neupane DP, Dulal HP, and Song J. (2021). Enteric fever diagnosis: current challenges and future directions. Pathogens. 10(4), 410. https://doi.org/10.3390/pathogens10040410
2020
Lee S*, Yang Y-A* (* co-first author), Milano SK, Nguyen T, Ahn C, Sim JH, Thompson AJ, Hillpot EC, Yoo G, Paulson JC, and Song J. (2020). Salmonella typhoid toxin PltB subunit and its nontyphoidal Salmonella orthologue confer differential host adaptation and virulence. Cell Host & Microbe. 27: 1-13. DOI:10.1016/j.chom.2020.04.005
Highlighted in Previews (Cell Host & Microbe 2020, 27(6): 851-853).
Structure of typhoid toxin PltB+α2-3 glycan(Neu5Ac-α2-3-Gal-β1-4-GlcNAc): PDB 6P4M
Structure of typhoid toxin PltB+α2-6 glycan (Neu5Ac-α2-6-Gal-β1-4-GlcNAc): PDB 6P4N
Structure of PltBN29K: PDB 6P4P
Structure of PltBN29K+α2-3 glycan (Neu5Ac-α2-3-Gal-β1-4-GlcNAc): PDB 6P4Q
Structure of PltBN29K+α2-6 glycan (Neu5Ac-α2-6-Gal-β1-4-GlcNAc): PDB 6P4R
Structure of PltBT65I: PDB 6P4S
Structure of PltBT65I+α2-3 glycan (Neu5Ac-α2-3-Gal-β1-4-GlcNAc): PDB 6P4T
Nguyen T*, Lee S* (* co-first author), Yang Y-A, Ahn C, Sim JH, Kei TG, Barnard KN, Yu H, Millano SK, Chen X, Parrish CR, and Song J. (2020). The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication. PLOS Pathogens. 16(2): e1008336. DOI: 10.1371/journal.ppat.1008336
Structure of typhoid toxin PltB+9OAc-α2-3 glycan (Neu5,9Ac2α2-3Galβ1-4GlcNAcβProN3): PDB 6TYN
Structure of typhoid toxin PltB+4OAc-α2-3 glycan (Neu4,5Ac2α2-3Galβ1-4GlcNAcβProN3): PDB 6TYO
Structure of typhoid toxin PltB+9OAc-α2-6 glycan Neu5,9Ac2α2-6Galβ1-4GlcNAcβProN3): PDB 6TYQ
2019
Yang Y, Higgins C, Rehman I, Galvao K, Brito I, Bicalho M, Song J, Wang H, and Bicalho R. (2019). The genomic diversity, virulence, and antimicrobial resistance of Klebsiella pneumoniae from cows and humans. Applied and Environmental Microbiology. 85 (6): e02654-18. DOI: 10.1128/AEM.02654-18
2018
Yang Y-A, Chong A, and Song J. (2018). Why is Eradicating Typhoid Fever So Challenging: Implications for Vaccine and Therapeutic Design. Vaccines. 6 (3), 45. DOI: 10.3390/vaccines6030045
Yang Y-A, Lee S, Zhao J, Thompson AJ, McBride R, Tsogtbaatar B, Paulson JC, Nussinov R, Deng L, and Song J. (2018). In vivo tropism of Salmonella Typhi toxin to cells expressing a multiantennary glycan receptor. Nature Microbiology. 3 (2): 155-163. Epub Dec 4, 2017. DOI: 10.1038/s41564-017-0076-4
Highlighted in News and Views (Nature Microbiology 3 (2): 124-126.)
2017
Liu Y, Qi L, Qi L, Ding T, Wang Z, Fu J, Hu M, Li M, Song J**, and Liu X**. (2017). Temporal regulation of a Salmonella Typhimurium virulence factor by the transcriptional regulator YdcR. Molecular & Cellular Proteomics. 16 (9):1683-1693. DOI: 10.1074/mcp.M117.068296
Chong, A, Lee, S, Yang, Y-A, and Song J. (2017). The role of typhoid toxin in Salmonella Typhi virulence. Yale Journal of Biology & Medicine. 90 (2):283-290. PMCID: PMC5482304
2016
Chang S-J, Song J, and Galán JE. (2016). Receptor-mediated sorting of typhoid toxin during its export from Salmonella Typhi-infected cells. Cell Host & Microbe. 20 (5):682-689. DOI: 10.1016/j.chom.2016.10.005
Song J*, Wilhelm CL* (* co-first author), Wangdi T, Maira-Litran T, Lee S-J, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Baumler AJ, Pier GB, Galán JE, and Yarovinsky F. (2016). Absence of TLR11 in mice does not confer susceptibility to Salmonella Typhi. Cell. 164 (5):827-8. . DOI: 10.1016/j.cell.2016.02.015
2014
Deng L*, Song J* (* co-first author), Gao X*, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galán JE, and Varki A. (2014). Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Cell. 159 (6):1290-9. DOI: 10.1016/j.cell.2014.10.057
Selected previous publications
Song J*, Gao X* (* co-first author), and Galán JE. (2013). Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin. Nature. 499(7458):350-354. DOI: 10.1038/nature12377.
Highlighted in News and Views, Highlighted in Faculty 1000
Structure of typhoid toxin: PDB 4K6L
Song J*, Willinger T* (* co-first author), Rongvaux A, Eynon EE, Stevens S, Manz MG, Flavell RA, and Galán JE. (2010). A mouse model for the human pathogen Salmonella Typhi. Cell Host & Microbe. 8(4):369-76. DOI: 10.1016/j.chom.2010.09.003
Song J*, Bishop BL*, Li G, Grady R, Stapleton A, and Abraham SN. (2009). TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. Proc Natl Acad Sci USA. 106(35):14966-71. (* co-first authors). DOI: 10.1073/pnas.0900527106
Song J**, and Abraham SN. (2008). TLR-mediated immune responses in the urinary tract. Current Opinion in Microbiology. 11(1):66-73. (** corresponding author). DOI: 10.1016/j.mib.2007.12.001
Song J**, and Abraham SN. (2008). Innate and adaptive immune responses in the urinary tract. European Journal of Clinical Investigation. 2:21-8. (** corresponding author). DOI: 10.1111/j.1365-2362.2008.02005.x
Song J, Bishop BL, Li G, Duncan MJ, and Abraham SN. (2007). TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. Cell Host & Microbe. 1(4):287-298. DOI: 10.1016/j.chom.2007.05.007
Highlighted as a Featured Article
Song J, Duncan MJ, Li G, Chan C, Grady R, Stapleton A, and Abraham SN. (2007). A novel TLR4 mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. PLOS Pathogens. 3(4):e60. (Highlighted as Cover Story, Highlighted in Editor’s pick). DOI: 10.1371/journal.ppat.0030060
Bishop BL, Duncan MJ, Song J, Li G, Zaas D, and Abraham SN. (2007). Cyclic AMP-regulated exocytosis of E. coli from infected bladder epithelial cells. Nature Medicine. 13(5):625-630. (Highlighted in News and Views). DOI: 10.1038/nm1572