Typhoid toxin and Salmonella Typhi Pathogenesis (Song Lab at Cornell; September 2014 – present)
Yang Y, Higgins C, Rehman I, Galvao K, Brito I, Bicalho M, Song J, Wang H, and Bicalho R. (2018). The genomic diversity, virulence, and antimicrobial resistance of Klebsiella pneumoniae from cows and humans. Applied and Environmental Microbiology. AEM.02654-18 [Epub ahead of print].
Yang Y-A, Chong A, Song J. (2018). Why is Eradicating Typhoid Fever So Challenging: Implications for Vaccine and Therapeutic Design. Vaccines. 6(3), 45; https://doi.org/10.3390/vaccines6030045 – Review article.
Yang Y-A, Lee S, Zhao J, Thompson AJ, McBride R, Tsogtbaatar B, Paulson JC, Nussinov R, Deng L, Song J. (2018). In vivo tropism of Salmonella Typhi toxin to cells expressing a multiantennary glycan receptor. Nature Microbiology. 3(2): 155-163. Epub Dec 4, 2017. (Highlighted in News and Views of the Journal; Nature Microbiology 3(2): 124-126.).
Liu Y, Qi L, Qi L, Ding T, Wang Z, Fu J, Hu M, Li M, Song J**, Liu X**. (2017). Temporal regulation of a Salmonella Typhimurium virulence factor by the transcriptional regulator YdcR. Molecular & Cellular Proteomics. 16(9):1683-1693. (** co-senior author).
Chong, A, Lee, S, Yang, Y-A, Song J. (2017). The role of typhoid toxin in Salmonella Typhi virulence. Yale Journal of Biology & Medicine. 90(2):283-290. – Review article.
Chang S-J, Song J, Galán JE. (2016). Receptor-mediated sorting of typhoid toxin during its export from Salmonella Typhi-infected cells. Cell Host Microbe. 20(5):682-689.
Song J*, Wilhelm CL*, Wangdi T, Maira-Litran T, Lee S-J, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Baumler AJ, Pier GB, Galán JE, Yarovinsky F. (2016). Absence of TLR11 in mice does not confer susceptibility to Salmonella Typhi. Cell. 164(5):827-8. (* co-first author).
Deng L*, Song J*, Gao X*, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galán JE, and Varki A. (2014). Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Cell. 159(6):1290-9. (* co-first author).
Selected previous publications on the host-bacterial pathogen interaction
Typhoid toxin & Salmonella Typhi Pathogenesis (Postdoc training; January 2009-August 2014)
Song J*, Gao X*, and Galán JE. (2013). Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin. Nature. 499(7458):350-354. (* co-first author; Highlighted as News and Views by the journal, Highlighted by Faculty 1000).
Song J*, Willinger T*, Rongvaux A, Eynon EE, Stevens S, Manz MG, Flavell RA, and Galán JE. (2010). A mouse model for the human pathogen Salmonella Typhi. Cell Host Microbe. 8(4):369-76. (* co-first author).
ScienceDaily: Typhoid Mary, not typhoid mouse: Enzyme protects mice, not humans from typhoid.
Medica Press: Typhoid Mary, not typhoid mouse: Lack of enzyme explains why typhoid fever is a human-specific disease
NIH RESEARCH MATTERS: Novel Structure and Function of Typhoid Toxin
Science News: Lethal Power of Typhoid Bacteria Salmonella Typhi Lies in Its Toxin
Nature News & Views: Bacteriology: Toxins in tandem
Interplay between bladder epithelial cells and uropathogenic E. coli (PhD student; 2003-2008)
Song J*, Bishop BL*, Li G, Grady R, Stapleton A, and Abraham SN. (2009). TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. Proc Natl Acad Sci USA. 106(35):14966-71. (* co-first author).
Song J**, and Abraham SN. (2008). TLR-mediated immune responses in the urinary tract. Current Opinion in Microbiology. 11(1):66-73. (** corresponding author). – Review article.
Song J**, and Abraham SN. (2008). Innate and adaptive immune responses in the urinary tract. European Journal of Clinical Investigation. 2:21-8. (** corresponding author). – Review article.
Song J, Bishop BL, Li G, Duncan MJ, and Abraham SN. (2007). TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. Cell Host Microbe. 1(4):287-298. (Highlighted as a Featured article by the journal).
Song J, Duncan MJ, Li G, Chan C, Grady R, Stapleton A, and Abraham SN. (2007). A novel TLR4 mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. PLoS Pathogens. 3(4):e60. (Highlighted as Cover Story, Highlighted as Editor’s pick).
Bishop BL, Duncan MJ, Song J, Li G, Zaas D, and Abraham SN. (2007). Cyclic AMP-regulated exocytosis of E. coli from infected bladder epithelial cells. Nature Medicine. 13(5):625-630. (Highlighted as News and Views by the journal).
Cover Story: Bladder epithelial cells exposed to E. coli.
News and Views: Flushing bacteria out of the bladder